Bonjour à tous

I am a french postdoc working with Cécile Ané at the statistic department of the University of Wisconsin at Madison. I am working here on statistical issues for phylogeny. I completed my PhD at the Laboratory of Statistics and Probability (LSP) of Paul Sabatier's university , Toulouse, and at the French National Institute for Agricultural Research (INRA). My supervisors were Jean-Marc Azais (LSP), Céline Delmas (INRA) and Jean-Michel Elsen (INRA). The area of research of my PhD was QTL detection. I worked on selective genotyping and also on the limit process defined by the Interval mapping.

My email address

rabieratstat.wisc.edu

What is a QTL ?

QTL means Quantitative trait loci. It is any locus responsible for the variation of a quantitative trait.On this picture, you can see some plamtrees which comes from Lanzarote (Canary Islands). We may wonder why the first palmtree is largely taller than the others. There is maybe a QTL responsible for this particularity.In order to locate the QTL, people scan the genome of the palmtrees and do a statistical test at each position. That is the principle of interval mapping (Lander and Botstein 89). As a lot of tests are performed on the genome, we are confronting to multiplicity problem. The work of Benjamini and Hochberg (95) on the false discovery rate is a way to deal with this problems of multi testing. Another approach is to study the stochastic process defined by all the correlated tests performed along the genome. I study the asymptotic properties of such a process. The Matlab pictures on the top of this web page represent this correlation. On the other hand, genotyping is very expensive. That's why Lebotwitz (1987) has proposed to genotype only indiviuals with extreme phenotypes : it is selective genotyping. I study the asymptotic properties of such a design.